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The Impact of the hsCRP/BMI Ratio on Cardiovascular Outcomes in CAD Patients: A Population-Based Study
Da Liu1, Xuliang Wang2, Kuo Zhang3
1The Second Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518055, China.
Insights
A higher high sensitivity C-reactive protein (CRP) to body mass index (BMI) ratio (CBR) is linked to increased risks of major adverse cardiovascular and cerebrovascular events (MACCEs) and myocardial infarction (MI) in patients with drug-eluting stents (DES). This finding highlights CBR as a potential predictor of adverse outcomes post-DES implantation.
Area of Science:
- Cardiovascular Medicine
- Biomarkers
- Interventional Cardiology
Background:
- Uncertainty exists regarding the association between the novel high sensitivity C-reactive protein (hsCRP)-to-body mass index (BMI) ratio (CBR) and adverse events in patients after drug-eluting stent (DES) implantation.
- The CBR combines inflammatory marker hsCRP and metabolic indicator BMI, potentially offering a composite risk assessment.
Purpose of the Study:
- To prospectively evaluate the association between the CBR and the occurrence of adverse cardiovascular and cerebrovascular events in subjects who underwent DES implantation.
- To determine if the CBR can serve as a predictive indicator for adverse outcomes in this patient population.
Main Methods:
- A prospective cohort study enrolled 9810 subjects who received DES implantation between January 2013 and December 2013.
- Participants were stratified into three groups based on their CBR.
- Major adverse cardiovascular and cerebrovascular events (MACCEs), including all-cause death, myocardial infarction (MI), stroke, and target vessel revascularization (TVR), were tracked over a mean follow-up of 26.7 months using Kaplan-Meier and Cox regression analyses.
Main Results:
- A total of 1022 MACCEs were recorded, with 122 deaths, 392 MIs, 156 strokes, and 461 TVRs.
- Kaplan-Meier analysis indicated that MACCE and MI rates increased progressively with higher tertiles of the CBR.
- Cox regression analysis confirmed a significant association between a higher CBR and an elevated risk of MACCE and MI.
Conclusions:
- In patients who have undergone DES implantation, a higher CBR is significantly associated with an increased long-term risk of MACCE and MI.
- The CBR may serve as a valuable composite biomarker for predicting adverse cardiovascular and cerebrovascular outcomes following DES implantation.
Background:
It remains uncertain whether a novel composite indicator, the high sensitivity C-reactive protein (CRP) (hsCRP)-to-body mass index (BMI) ratio (CBR), is associated with unfavourable events in subjects who have undergone drug-eluting stent (DES) implantation. Therefore, we conducted a prospective cohort study to evaluate the associations between the CBR and adverse outcome occurrences.
Methods:
From January 2013 to December 2013, a total of 9810 subjects who underwent DES implantation were enrolled in the study. The participants were divided into three groups on the basis of the CBR. We defined the primary endpoint as the occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs), and the secondary endpoints included the occurrence of all-cause death, myocardial infarction(MI), stroke or target vessel revascularization (TVR). Kaplan‒Meier (K‒M) analysis and Cox regression analysis were performed to assess the discrepancy in the risk of adverse outcomes between the different CBR groups.
Results:
Over an average follow-up period of 26.7 months, 1022 MACCEs were recorded, which included 122 deaths, 392 MIs, 156 strokes and 461 instances of TVR. The results from the K‒M analysis suggested that the rates of MACCEs and MI increased with increasing tertiles of the CBR. Furthermore, Cox regression analysis demonstrated that there were significant associations between a high CBR and increased MACCE and MI risk.
Conclusion:
In subjects who underwent DES implantation, a higher CBR was significantly related to increased long-term MACCE and MI risk.
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