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Association Between Cerebral Blood Flow Velocity and Neurological Outcomes After Cardiac Arrest: A Retrospective
Saki Yamamoto1, Ginga Suzuki1, Tsuneyoshi Yakuwa2
1Critical Care Center, Toho University Omori Medical Center, Tokyo, JPN.
Cureus
|December 3, 2025
Summary
Time-averaged maximum flow velocity (TAMX) measured by transcranial color flow imaging (TCCFI) may predict neurological outcomes in cardiac arrest (CA) survivors. Medium TAMX levels correlated with better neurological recovery compared to high levels, suggesting its potential as a bedside prognostic tool.
Area of Science:
- Neurology
- Critical Care Medicine
- Medical Imaging
Background:
- Neurological outcomes post-cardiac arrest (CA) present a significant clinical challenge.
- Transcranial ultrasound-measured time-averaged maximum flow velocity (TAMX) is a potential prognostic indicator, but its clinical utility requires further investigation.
- This study explored the association between TAMX, assessed via transcranial color flow imaging (TCCFI), and neurological prognosis in CA patients.
Purpose of the Study:
- To investigate the relationship between TAMX measured by TCCFI and neurological outcomes in patients following cardiac arrest.
- To determine if TAMX can serve as a reliable predictor of neurological recovery in the post-CA population.
Main Methods:
- A retrospective, single-center study included 41 intensive care unit (ICU) patients with initial ventricular fibrillation (VF) post-CA.
- Exclusion criteria included age <18 years and development of cerebral hemorrhage or infarction.
- Logistic regression analysis was employed to assess the association between TAMX (categorized as low, medium, high) and cerebral performance category (CPC) at discharge, adjusting for key physiological variables.
Main Results:
- TAMX demonstrated a significant association with good neurological outcomes (CPC 1-2).
- The medium TAMX group exhibited a significantly higher rate of good neurological outcomes (78.9%) compared to the high TAMX group (30.8%, p=0.01).
- Adjusted analyses confirmed that medium TAMX levels were significantly linked to favorable CPC outcomes relative to high TAMX levels.
Conclusions:
- TAMX, measured by TCCFI, shows potential as a prognostic marker for neurological outcomes in post-CA patients.
- Medium TAMX levels are associated with improved neurological recovery compared to high levels.
- Further research is essential to validate these findings and elucidate the underlying pathophysiological mechanisms linking TAMX to neurological prognosis.
