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Sequential hydrogen-release implant for promoting the soft tissue integration through immunomodulatory and
Yue Yuan1, Zishuo Hou2, Miaomiao Chen1
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implants, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710072, PR China.
This study introduces a novel hydrogen (H2)-releasing implant that enhances soft tissue integration around dental implants. The implant precisely controls H2 release to modulate the immune response and promote tissue remodeling for improved implant success.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Immunology
Background:
- Dental implant success is limited by weaker soft tissue integration compared to natural teeth.
- Developing strategies to improve soft tissue integration is crucial for long-term implant survival.
Purpose of the Study:
- To develop an on-demand, long-lasting hydrogen (H2)-releasing implant for enhanced soft tissue integration.
- To precisely regulate soft tissue integration through immunomodulation and pro-remodeling coupling.
Main Methods:
- Designed an H2-releasing implant responding to acidic microenvironments during inflammation.
- Utilized a hierarchical nanostructure for sustained H2 release during tissue remodeling.
- Investigated H2's effect on macrophage polarization, collagen formation, and angiogenesis.
Main Results:
- The implant released H2 on-demand, eliminating 73.6% of reactive oxygen species and inducing M2 macrophage polarization.
- Sustained H2 release promoted collagen fiber formation and angiogenesis.
- H2 activated MAPK signaling in fibroblasts and endothelial cells, stimulating pro-angiogenic factors.
Conclusions:
- The developed H2-releasing implant effectively enhances soft tissue integration by sequentially regulating the inflammatory and remodeling phases.
- This technology shows significant potential for improving the long-term success of dental implants.
