Related Experiment Video
Updated: Jan 6, 2026

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
Published on: October 7, 2017
Remimazolam in elderly patients undergoing EBUS-TBNA: protocol for a randomized clinical trial
Yeqin Liu1, Yuqin Chen1, Longxiang Ma1
1Department of Anesthesiology, Yan'an Hospital of Kunming City, Kunming, China.
Background:
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) remains the diagnostic benchmark for mediastinal staging, though geriatric patients require optimized anesthesia due to compromised pharmacokinetics and elevated perioperative risks.
Methods:
A prospective, double-blinded, randomized controlled clinical trial is conducted at a tertiary hospital. Sixty eligible patients aged over 70 years who underwent EBUS-TBNA under general anesthesia were enrolled. Participants were randomized 1:1 to receive either propofol (Group P, n = 30) or remimazolam besylate (Group R, n = 30) with protocolized perioperative management. Primary outcome assessed anesthesia emergence quality. Secondary outcomes encompassed serial hemodynamics, cumulative vasoactive drug requirements, recovery metrics (time/quality), 24-hour QoR-40 scores, and perioperative complications.
Discussion:
This randomized trial compared remimazolam and propofol for EBUS-TBNA anesthesia in elderly patients. Remimazolam demonstrated accelerated Steward recovery and enhanced hemodynamic stability, whereas propofol exhibited risks of adipose tissue deposition and hypotension. These pharmacodynamic profiles inform anesthetic optimization in geriatric cohorts, necessitating multicenter validation of age-adjusted protocols.
More Related Videos
08:33Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
Published on: January 5, 2024
07:02A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
Related Concept Videos
REM Sleep Behavior Disorder
RBD is significantly associated with...
Pharmacodynamics in Geriatric Patients: Effects of Age
Blind Procedures
Drug Dosing: Geriatric Patients
Bioavailability Study Design: Healthy Subjects Versus Patients
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...