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Updated: Jan 9, 2026
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Hypofractionated Spot Scanning Proton Therapy for Head and Neck Mucosal Melanoma: A Retrospective Analysis With
Koichiro Nakajima1, Hiromitsu Iwata1, Gaku Takano2
1Department of Radiation Oncology, Nagoya Proton Therapy Center, Nagoya City University West Medical Center, Nagoya, Japan.
Objective:
To evaluate clinical outcomes and quality of life (QOL) following hypofractionated spot-scanning proton therapy (SSPT) for head and neck malignant mucosal melanoma (HNMM).
Methods:
This retrospective study included 39 patients treated with SSPT (60-64 Gy[RBE] in 15-16 fractions) between 2013 and 2023. Endpoints included overall survival (OS), local control (LC), progression-free survival (PFS), toxicities, and QOL.
Results:
Most tumors were located in the sinonasal cavity (n = 32). Surgery was performed in 8 patients; 19 received immune checkpoint inhibitors post-SSPT. The 3-year OS, LC, and PFS were 50%, 83%, and 30%, respectively. Larger tumor volumes (≥ 20 cm3) were linked to worse PFS. Grade 3 mucositis occurred in 13%. Late toxicities included sinus disorder, osteonecrosis, and blindness (3%-5%). QOL was largely preserved, with notable declines in pain, swallowing, and mouth opening.
Conclusion:
SSPT provides favorable LC with acceptable toxicity. Effective systemic therapies are needed to improve long-term outcomes.
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