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Candida auris: host interactions, antifungal drug resistance, and diagnostics

Anuradha Chowdhary1, Michail S Lionakis2, Neeraj Chauhan3

  • 1Medical Mycology Unit, Department of Microbiology, and the National Reference Laboratory for Antimicrobial Resistance in Fungal Pathogens, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi, India.

Microbiology and Molecular Biology Reviews : MMBR
|December 3, 2025
PubMed

Insights

Invasive fungal infections caused by Candida auris are a growing global threat, leading to high mortality and challenging treatment due to multidrug resistance and skin colonization. Addressing diagnostic delays and transmission is crucial to combat this serious pathogen.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Public Health

Background:

  • Invasive fungal infections impact millions globally, with high mortality rates.
  • Candida auris is a multidrug-resistant yeast causing significant concern due to skin colonization and transmission.
  • Delayed diagnosis and misidentification of C. auris hinder effective antifungal treatment.

Purpose of the Study:

  • To summarize the global burden of Candida auris infections.
  • To review antifungal drug resistance mechanisms and factors influencing skin colonization.
  • To outline current diagnostic methods and future challenges in combating C. auris.

Main Methods:

  • Literature review of global candidiasis burden.
  • Analysis of antifungal resistance mechanisms in C. auris.
  • Examination of host and fungal factors in skin colonization.
  • Evaluation of current diagnostic strategies for C. auris.

Main Results:

  • Candida auris poses a significant global health challenge with high mortality.
  • Multidrug resistance and persistent skin colonization facilitate C. auris spread.
  • Diagnostic inaccuracies lead to delayed and inappropriate antifungal therapies.

Conclusions:

  • Effective strategies are needed to address the global burden of C. auris.
  • Understanding resistance and colonization is key to controlling transmission.
  • Improved diagnostics and treatment are essential to reduce mortality from C. auris infections.
Keywords:
Candida aurisantifungal drug resistancehost immune responseskin colonization

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