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Bidirectional relationships between depression and asthma.
Brittany Duchene1, Anne E Dixon1
1Department of Medicine, University of Vermont, Burlington, VT, USA.
Expert Review of Respiratory Medicine
|December 3, 2025
Summary
Asthma and depression share common risk factors and biological pathways. Treating depression may improve asthma symptoms, highlighting the need for further research into this connection.
Area of Science:
- Pulmonary Medicine
- Psychiatry
- Epidemiology
Background:
- Asthma and depression are prevalent global diseases impacting morbidity and mortality.
- Both conditions share common epidemiologic traits and are independent risk factors for each other.
Purpose of the Study:
- To review and assess the evidence linking asthma and depression.
- To explore shared epidemiological characteristics, risk factors, and pathophysiological mechanisms.
Main Methods:
- A literature review was conducted using PubMed.
- The review focused on studies examining the relationship between asthma and depression.
Main Results:
- Asthma and depression exhibit similar epidemiology, risk factors (genetic, maternal, socioeconomic), and pathophysiological pathways (cytokine signaling).
- Despite shared characteristics, few studies investigate the impact of depression treatment on asthma outcomes.
Conclusions:
- The intersection of asthma and depression is significant, suggesting that treating comorbid depression could enhance asthma outcomes.
- Further research is warranted to investigate the effects of antidepressant therapy in patients with comorbid asthma and depression.
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