Bipolar Percutaneous Endocardial Septal Radiofrequency Ablation (Bi-PESA): First-in-Human Application for
Aiju Tian1, Yuhe Jia1, Minghu Xiao2
1Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
JACC. Case Reports
|December 3, 2025
Summary
Combined bipolar and percutaneous endocardial septal radiofrequency ablation (Bi-PESA) offers a new treatment for drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). This novel approach effectively reduced the left ventricular outflow tract gradient and improved patient symptoms.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Technology
Background:
- Drug-refractory hypertrophic obstructive cardiomyopathy (HOCM) presents treatment challenges for patients unsuitable for surgery or alcohol septal ablation.
- Conventional unipolar radiofrequency ablation offers limited relief due to shallow lesion depth.
- Bipolar radiofrequency ablation, effective for ventricular arrhythmias, has not been explored for HOCM.
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