Patients' knowledge influences practice via attitudes toward hyperuricaemia: a mediation analysis
Hong Shi1, Yanrong Zhu2, Qianyu Guo1
1Department of Rheumatology and Immunology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, 99 Longcheng Street, Taiyuan, Xiaodian District, 030032, China.
Clinical Rheumatology
|December 3, 2025
Summary
Patients with hyperuricaemia show good knowledge and attitudes, with knowledge influencing practices through attitude. Educational interventions should focus on improving attitudes, particularly in asymptomatic patients, for better self-management.
Area of Science:
- Metabolic Disorders
- Health Psychology
- Patient Education
Background:
- Hyperuricaemia is a common metabolic disorder linked to gout and cardiovascular issues.
- Understanding patient knowledge, attitudes, and practices (KAP) is crucial for effective management.
- Attitude may mediate the relationship between knowledge and practice in hyperuricaemia patients.
Purpose of the Study:
- To assess KAP regarding hyperuricaemia among patients.
- To investigate the mediating role of attitude in the knowledge-practice relationship.
- To identify subgroups where attitude mediation is more pronounced.
Main Methods:
- Cross-sectional study conducted from July to August 2023.
- 406 hyperuricaemia patients completed questionnaires.
- Structural equation modeling used to analyze KAP relationships.
Main Results:
- Patients generally had adequate knowledge (54.34±8.68) and positive attitudes (23.40±2.36).
- Knowledge significantly impacted attitude (β=0.072, P=0.009), and attitude significantly impacted practice (β=0.781, P=0.015).
- Attitude fully mediated the effect of knowledge on practice (β=0.056, P=0.003), especially in asymptomatic patients.
Conclusions:
- Hyperuricaemia patients possess adequate knowledge and positive attitudes.
- Knowledge influences practice indirectly through attitude, particularly in asymptomatic individuals.
- Targeted interventions to improve patient attitudes are recommended for enhanced self-management, especially for those without gout symptoms.
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