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Updated: Jan 9, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Rare variant hemoglobin Köln in Southern India-an underdiagnosed entity?
Swathi Kulkarni1, Deepalakshmi D Putchen2, Pradeep Kumar Venkatachala3
1Department of Hematology, Neuberg Anand Reference Laboratory, a unit of Neuberg Diagnostics Pvt. Ltd., Anand Tower, 54, Bowring Hospital Road, Shivajinagar, Bengaluru, 560001, Karnataka, India. drswathik@neubergdiagnostics.com.
This case study highlights the misdiagnosis of a boy with unstable hemoglobin, Hb Köln. Capillary electrophoresis and WBC scattergram analysis proved crucial for accurate diagnosis, emphasizing their role in identifying hemolytic anemias.
Area of Science:
- Hematology
- Clinical Diagnostics
Background:
- Unexplained hemolysis can be challenging to diagnose.
- Hemoglobinopathies, such as HbE/β-thalassemia, are common but can be misdiagnosed.
- Unstable hemoglobins are a less common cause of hemolysis.
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