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Related Experiment Video

Updated: Jan 9, 2026

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
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Random-Start Approach in Breast Cancer Patients: Are All Menstrual Cycle Phases the Same?

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|December 3, 2025
PubMed
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Fertility preservation for breast cancer patients shows no difference in oocyte yield regardless of menstrual cycle phase. Ovarian stimulation timing did not impact outcomes in women undergoing random-start protocols.

Keywords:
ARTFertility preservationLetrozoleOvarian stimulation

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Area of Science:

  • Reproductive Endocrinology
  • Oncology
  • Infertility Management

Background:

  • Breast cancer survivors often seek fertility preservation.
  • Ovarian stimulation protocols can be initiated at various points in the menstrual cycle.
  • Understanding the impact of cycle phase on ovarian response is crucial for optimizing fertility treatments.

Purpose of the Study:

  • To investigate the ovarian response in breast cancer patients undergoing fertility preservation.
  • To compare oocyte yield and ovarian sensitivity based on the phase of the menstrual cycle at which ovarian stimulation begins.

Main Methods:

  • Retrospective study of 113 breast cancer patients undergoing oocyte cryopreservation.
  • Comparison of follicular phase (FP) versus luteal phase (LP) initiation of ovarian stimulation (OS).
  • Stratification into early follicular (EFP), late follicular (LFP), early luteal (ELP), and late luteal (LLP) phases.

Main Results:

  • No significant differences in oocytes retrieved or ovarian sensitivity were found between follicular and luteal phases.
  • No differences in oocyte yield or ovarian sensitivity were observed across the four stratified menstrual cycle phases.
  • Ovarian stimulation was significantly shorter when initiated during the early follicular phase.

Conclusions:

  • The timing of ovarian stimulation initiation within the menstrual cycle does not influence oocyte yield or ovarian sensitivity in breast cancer patients.
  • Random-start protocols with letrozole are effective regardless of the menstrual cycle phase.
  • Future research should address the study's limitations, including its retrospective design and small sample size.