SimICD: A Closed-Loop Simulation Framework For ICD Therapy.

Area of Science:

• Biomedical Engineering
• Computational Cardiology
• Medical Device Simulation

Background:

• Virtual studies are vital for implantable cardioverter-defibrillator (ICD) testing before clinical use.
• Existing models lack the ability to simulate ICD therapy progression during arrhythmias.

Purpose of the Study:

• To introduce SimICD, a simulation tool for modeling ICD logic and cardiac electrophysiology.
• To enable simulation of ICD therapy progression for various tachy-arrhythmia episodes.

Main Methods:

• SimICD combines virtual ICD algorithms with cardiac electrophysiology simulations in a feedback loop.
• A cohort of virtual patients was used to test the simulation's capabilities.

Main Results:

• SimICD successfully simulated realistic cardiac signals and ICD responses.
• The tool's outputs align with the logic of real-world ICD devices.
• Demonstrated potential for facilitating ICD parameter reprogramming.

Conclusions:

• SimICD provides a viable platform for in silico testing of ICD therapy progression.
• The tool can aid in optimizing ICD programming for specific arrhythmic episodes.
• Facilitates advanced research and development in cardiac device therapy.