Functional network connectivity in white matter: A spatially-guided ICA-based network approach
Summary
Schizophrenia disrupts brain connectivity by altering white matter (WM) network stability. Our study reveals significant WM functional dysconnectivity, offering potential biomarkers for early diagnosis and targeted interventions.
Area of Science:
- Neuroscience
- Psychiatric Disorders
- Brain Connectivity
Background:
- White matter (WM) is crucial for brain connectivity, but its functional role is not fully understood.
- Schizophrenia (SZ) is associated with widespread brain network alterations.
- Accurate analysis of WM intrinsic connectivity networks (ICNs) is essential for understanding neurological disorders.
Purpose of the Study:
- To investigate functional connectivity alterations in white matter (WM) in schizophrenia (SZ).
- To utilize a large-scale WM ICN template and advanced ICA methods for robust analysis.
- To explore both static (sFNC) and dynamic (dFNC) functional connectivity in SZ.
Main Methods:
- Employed a multi-scale WM ICN template from over 100,000 scans.
- Used spatially constrained ICA (scICA) with MOO-ICAR for subject-specific WM ICN extraction.
- Conducted static and dynamic functional connectivity analyses on the FBIRN dataset.
Main Results:
- Identified significant WM functional dysconnectivity in SZ, affecting subcortical-paralimbic, sensorimotor, and frontal networks.
- Observed increased transition rates and reduced dwell times in dynamic functional connectivity (dFNC) in SZ (p < 0.05).
- Highlighted disrupted stability in key functional states within WM networks in individuals with SZ.
Conclusions:
- White matter (WM) plays a vital role in maintaining functional network stability, and its disruption is implicated in schizophrenia.
- WM functional dysconnectivity and altered network dynamics may serve as potential biomarkers for SZ.
- This research refines WM connectivity analysis and advances dynamic network research in psychiatric disorders, with clinical relevance for diagnosis and treatment.
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