Related Experiment Video
Updated: Aug 19, 2026
08:03
Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice
Published on: April 15, 2014
Relation of measles virus to encephalitogenic factor with reference to the aetiopathogenesis of multiple sclerosis
Journal of Neurology, Neurosurgery, and Psychiatry
|March 1, 1974
Abstract:
A combination of affinity chromatography with the macrophage electrophoretic migration (MEM) test has been used to study the antigenic similarities between encephalitogenic factor (EF) and measles virus. These have determinant(s) sufficiently closely related to account for the elevated level of circulating antibody to measles in multiple sclerosis.
Insights
This study investigated antigenic similarities between encephalitogenic factor (EF) and measles virus using affinity chromatography and the macrophage electrophoretic migration (MEM) test. Findings suggest closely related determinants may explain elevated measles antibodies in multiple sclerosis patients.
Area of Science:
- Immunology
- Virology
- Neuroscience
Background:
- Multiple sclerosis (MS) is a chronic neurological disease.
- Elevated antibodies to measles virus are observed in some MS patients.
- The role of viral antigens in MS pathogenesis is under investigation.
Purpose of the Study:
- To explore antigenic similarities between encephalitogenic factor (EF) and measles virus.
- To investigate the potential link between measles virus and MS pathogenesis.
- To understand the basis for elevated measles antibodies in MS.
Main Methods:
- Affinity chromatography was employed to isolate and purify relevant factors.
- The macrophage electrophoretic migration (MEM) test was utilized to assess antigenic similarities.
- Comparative analysis of EF and measles virus antigens was performed.
Main Results:
- Antigenic determinants of EF were found to be closely related to those of measles virus.
- This antigenic similarity provides a potential explanation for observed immune responses.
- Evidence suggests a cross-reactive immune response between EF and measles virus.
Conclusions:
- The study identifies significant antigenic overlap between EF and measles virus.
- This overlap may contribute to the immune response seen in multiple sclerosis.
- Further research is warranted to elucidate the precise mechanisms involved in MS pathogenesis.
More Related Videos
Related Concept Videos
01:18Viral Meningitis
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
01:28Rabies
Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
01:25Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
01:19Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...