Ex Vivo Porcine Liver Validation of Dixon Fat Fraction-Based Electrical Properties Models at 3T

Magnetic resonance electrical properties tomography (MR-EPT) is a non-invasive imaging technique for mapping tissue electrical properties (EPs), offering significant potential for disease diagnosis and ablation therapy. Previously proposed Dixon-based techniques for liver electrical properties (EPs) were established on literature values and lack exploration of individual differences. We developed a Dixon Fat Fraction Electrical Properties (FF-EPs) model and successfully reconstructed EPs from phantoms using this model. Differences in measurements between the FF-EPs technique and the open-end coaxial probe (OECP) method were investigated by ex vivo porcine livers experiments. The absolute error of the FF-EPs reconstructed permittivity is 2.43, and the absolute error of the conductivity is 0.125 S/m. This study validates the effectiveness of FF-EPs and holds promise for clinical application in acquiring patient liver EPs, thereby aiding in disease diagnosis and guiding ablation therapy.