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Electrophysiological Changes of Multi-site Local Field Potentials after Deep Brain Stimulation in the Medial
Summary
Deep brain stimulation (DBS) for treatment-resistant depression shows altered brain network connectivity. Acute medial prefrontal cortex (mPFC) DBS impacts functional connectivity, offering insights for optimizing DBS therapies.
Area of Science:
- Neuroscience
- Neurosurgery
- Psychiatry
Background:
- Depression is a leading cause of disability, with treatment resistance necessitating novel therapies like deep brain stimulation (DBS).
- Current DBS research for depression often overlooks the complex network interactions among multiple deep brain targets.
- Understanding these network dynamics is crucial for refining DBS efficacy.
Purpose of the Study:
- To investigate the acute effects of medial prefrontal cortex (mPFC) deep brain stimulation (DBS) on the brain network in depression.
- To analyze functional and directional connectivity changes between multiple depression-related brain regions following mPFC DBS.
Main Methods:
- Implantation of electrodes in twelve depression-related brain regions.
- Multi-site local field potential (LFP) analysis, including spectral analysis (PSD) and functional connectivity (iCOH).
- Directional connectivity analysis using the phase slope index (PSI).
Main Results:
- Acute mPFC DBS altered power spectral density (PSD) in the mPFC.
- Significant functional connectivity changes (iCOH) were observed between the mPFC and targets like the lateral habenula (LHb), subthalamic nucleus (STN), medial forebrain bundle (MFB), nucleus accumbens (NAc), and hippocampus (CA1).
- Connectivity changes were predominantly within the stimulated hemisphere, though directional analysis (PSI) revealed altered information flow between the left mPFC and contralateral regions.
Conclusions:
- This study provides crucial electrophysiological insights into the acute network effects of mPFC DBS in depression.
- Findings highlight the impact of mPFC DBS on functional and directional brain connectivity.
- Results may inform the optimization of DBS targets and parameters for treating depression.
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Related Concept Videos
01:41Action Potentials
Overview
01:14Action Potential
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
01:18Functions of the Nervous System
The nervous system is responsible for coordinating and regulating the body's functions. It functions through three main processes: sensory, integrative, and motor processes. Sensory function involves the detection and transmission of information about internal and external stimuli from sensory receptors to the CNS. The CNS processes this information through an integrative function, where it interprets and makes decisions based on the incoming sensory information. Finally, the motor function...
01:14Action Potential
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
01:28Action Potential: Phases of Stimulation
The action potential is a complex electrical event that occurs in excitable cells, such as neurons and muscle cells. It consists of several distinct phases, each with specific characteristics.
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...