GlauCUTU-WebXR: Virtual Reality Visual Field Perimetry System Embedded with Enhanced Humphrey Field Analyzer...

Area of Science:

• Ophthalmology
• Medical Technology
• Computer Science

Background:

• Glaucoma screening traditionally relies on methods like the Humphrey Field Analyzer (HFA), which can be time-consuming and costly.
• Existing custom hardware solutions for advanced screening may lack broad accessibility.
• There is a need for cost-effective and efficient glaucoma screening tools, especially in resource-limited settings.

Purpose of the Study:

• To introduce GlauCUTU-WebXR, an advanced glaucoma screening system utilizing commercial virtual reality (VR) devices and WebXR technology.
• To enhance the prediction accuracy of glaucoma sensitivity conversion from GlauCUTU to HFA sensitivity.
• To evaluate the efficiency and comparability of GlauCUTU-WebXR against the HFA.

Main Methods:

• Developed GlauCUTU-WebXR, integrating commercial VR hardware and WebXR for accessibility.
• Implemented an improved prediction model incorporating positional features (position index: PID) and severity classification metadata (SeverityScore).
• Trained and validated the model on 97 eyes (47 patients) and tested on 24 eyes (12 patients) with varying glaucoma severity.

Main Results:

• The enhanced model achieved a mean absolute error (MAE) of 4.3398 and a Pearson correlation of 0.8033 in converting GlauCUTU to HFA sensitivity.
• GlauCUTU-WebXR significantly reduced testing time compared to HFA (p<0.001).
• No significant differences in results were observed between GlauCUTU-WebXR and HFA across all glaucoma severity levels (none, mild, moderate, severe).

Conclusions:

• GlauCUTU-WebXR offers a cost-effective and efficient alternative for glaucoma screening.
• The system demonstrates high accuracy and comparability with HFA, improving accessibility through commercial VR hardware.
• This technology has the potential to enhance early glaucoma detection, particularly in underserved regions.