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Prototype Hardware for Closed-loop Stimulation of the Retina.

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    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |December 3, 2025
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    Summary

    Researchers developed an implantable hardware platform for adaptive retinal prostheses. This system enables real-time neural response evaluation, improving bionic vision for individuals with visual impairments.

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    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Ophthalmology

    Background:

    • Retinal prostheses aim to restore vision but face limitations in current stimulation strategies.
    • Manual tuning of stimulation parameters is impractical for high-acuity devices and ignores physiological variations.

    Purpose of the Study:

    • To present an implantable hardware platform for closed-loop retinal stimulation.
    • To enable adaptive, real-time optimization of stimulation for improved bionic vision.

    Main Methods:

    • Developed an implantable platform using commercial neural stimulating ASICs.
    • Designed for chronic operation, multi-electrode stimulation, and neural recording.
    • Evaluated a prototype in an in vivo pilot study (N=1).

    Main Results:

    • Confirmed the functionality of the hardware platform.
    • Demonstrated its capability for neural recording in vivo.
    • Validated the potential for closed-loop strategy development.

    Conclusions:

    • The developed platform supports the creation of adaptive closed-loop stimulation strategies.
    • This technology is crucial for advancing retinal prostheses and enhancing visual restoration.
    • Lays the groundwork for future improvements in bionic vision for end-users.