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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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New Cardiovascular Model Integrating Coronary Circulation in Obstructive and Non-Obstructive Hypertrophic

Francesca Menna, Joan Duprez, Adrien Al Wazzan

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |December 3, 2025
    PubMed

    Insights

    Hypertrophic cardiomyopathy (HCM) involves ischemia due to microcirculatory issues. Computational models reveal left ventricular outflow tract (LVOT) obstruction significantly impacts coronary blood flow in HCM patients.

    Area of Science:

    • Cardiovascular Physiology
    • Computational Biology
    • Medical Modeling

    Background:

    • Hypertrophic cardiomyopathy (HCM) is a complex cardiac condition.
    • HCM can present with ischemia despite the absence of coronary artery disease.
    • Microcirculatory abnormalities, potentially modulated by left ventricular outflow tract (LVOT) obstruction, are implicated in HCM-related ischemia.

    Purpose of the Study:

    • To develop and apply a model-based approach for analyzing the physiological mechanisms influencing coronary circulation in HCM.
    • To investigate the impact of LVOT obstruction on coronary blood flow at both macro- and microcirculatory levels.
    • To assess the utility of computational models in understanding HCM pathophysiology.

    Main Methods:

    • Development of a novel integrated cardiovascular model incorporating LVOT obstruction and coronary circulation.
    • Application of sensitivity analysis to identify key parameters affecting coronary flow.
    • Adaptation of the model to clinical data from two HCM patients (obstructive and non-obstructive).

    Main Results:

    • Sensitivity analysis identified critical parameters influencing coronary flow.
    • The degree of LVOT obstruction demonstrated a significant impact on coronary blood flow.
    • Model adaptation to HCM patients confirmed the substantial role of LVOT obstruction in microcirculatory alterations.

    Conclusions:

    • Computational models offer valuable insights into the effects of pathophysiological features on coronary circulation in HCM.
    • LVOT obstruction is a key factor influencing coronary microcirculation in HCM.
    • This modeling approach can aid in studying HCM, even with limited direct microcirculatory measurements.

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