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Related Concept Videos

Bode Plots Construction01:24

Bode Plots Construction

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The Bode plot is an essential tool in control system analysis, mapping the frequency response of a system through a magnitude plot and a phase plot, both against a logarithmic frequency axis. To construct a Bode plot, consider the transfer function H(ω):
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Related Experiment Video

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Performing In Vivo and Ex Vivo Electrical Impedance Myography in Rodents
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Assessment of Tissue Impedance Postmortem Using Needle Measurement and Computation Modelling.

Harshithaa Ganesan, Mari Lehti-Polojarvi, Annika Ahtiainen

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |December 3, 2025
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    Summary

    Electric bioimpedance measurement offers a minimally invasive method to assess kidney transplant quality. This study used computational modeling to track tissue degradation, providing insights into organ preservation.

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    Area of Science:

    • Biomedical Engineering
    • Organ Transplantation
    • Tissue Engineering

    Background:

    • Global organ transplant shortages necessitate improved preservation and diagnostic methods.
    • Understanding tissue degradation post-procurement is crucial for successful long-term transplant outcomes.
    • Current methods like biopsies are invasive and do not provide continuous real-time data.

    Purpose of the Study:

    • To investigate the potential of electric bioimpedance measurement as a tool for assessing organ quality.
    • To develop a computational model for translating in-tissue impedance measurements into electrical properties.
    • To characterize time-, temperature-, and depth-dependent changes in kidney tissue electrical properties.

    Main Methods:

    • Developed a homogeneous 3D computational model in COMSOL Multiphysics.
    • Collected in-tissue impedance measurement time series from porcine kidneys (procurement to 72h post-procurement).
    • Translated impedance data into tissue conductivity, relative permittivity, and capacitance time series.

    Main Results:

    • The computational model successfully translated experimental impedance data into electrical property time series.
    • Identified time-, temperature-, and tissue depth-dependent changes in electrical properties.
    • Established value ranges and trends indicative of kidney function and degradation processes.

    Conclusions:

    • Needle-based bioimpedance measurement provides a minimally invasive, real-time method for assessing kidney tissue condition.
    • Computational modeling of bioimpedance data facilitates the characterization of tissue degradation during organ preservation.
    • The findings offer valuable insights for improving kidney transplant quality assessment and preservation strategies.