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    Microfluidic chip surface textures influence human cortical organoid development. This study reveals how micro-scale topographies impact organoid morphogenesis, providing insights for future bioengineering applications.

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    Area of Science:

    • Biomedical Engineering
    • Developmental Biology
    • Neuroscience

    Background:

    • Microfluidic chips are increasingly used for biological research.
    • Fabrication processes can introduce unintended micro-scale surface topographies.
    • These topographies may affect biological processes within the chip.

    Purpose of the Study:

    • To investigate the impact of microfluidic chip surface topographies on human cortical organoid morphogenesis.
    • To establish a link between micro-scale surface features and organoid development.

    Main Methods:

    • Human cortical organoids were cultured and seeded into micro-wells with defined surface topographies.
    • In-incubator microscopy was used for continuous 21-day recording.
    • Computer vision and a morphological data processing pipeline analyzed organoid morphology.
    • Scanning electron microscopy and optical profilometry characterized micro-well surface topography.

    Main Results:

    • Inherent micro-scale surface topographies were identified in microfluidic chips.
    • A significant correlation was demonstrated between microfluidic surface topography and organoid morphogenesis.
    • Specific surface topographies biased the developmental trajectory of cortical organoids.

    Conclusions:

    • Microfluidic chip fabrication modalities can lead to surface topographies that influence organoid development.
    • Understanding and controlling surface topography is crucial for reproducible organoid culture.
    • This finding has implications for designing microfluidic devices for developmental biology and regenerative medicine.