Modeling the interplay between myelin architecture and local electromagnetic fields

Myelin plays a vital role in the functioning of the nervous system and is highly susceptible to damage in neurodegenerative diseases. This study investigates how alterations in electromagnetic fields associated with myelin can reflect its integrity. To achieve this, we developed a 3D microstructure model using finite element analysis and high-resolution imaging, enabling us to simulate electromagnetic field distributions. Unlike conventional models, our approach retains key microstructural details. Our findings demonstrate that the myelin microstructure significantly influences the distribution of electromagnetic fields, with variations in these fields potentially serving as indicators of myelin health. Furthermore, the analysis reveals that combining assessments of both electric and magnetic fields provides a more comprehensive understanding of myelin integrity.Clinical Relevance-This work offers a non-invasive framework for tracking disease progression by analyzing electromagnetic signatures, thus providing new insights into the mechanisms underlying neurodegenerative diseases.