Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TRIM65 accelerates VSMC-derived foam cell formation and arteriosclerosis progression by inhibiting mitophagy.

Molecular and cellular biochemistry·2026
Same author

Defect-Suppressed Molecular Passivation Film Endure the Trade-Off: Scalable Co-Passivation for Copper That Withstands Harsh Alkaline Attack.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Effects of encapsulated algae oil supplements on the production of docosahexaenoic acid-enriched milk in mid-lactation dairy cows.

JDS communications·2026
Same author

Taming Flexibility: Synergistic Pore and Polarity Engineering in a MOF for High-Efficiency Xe/Kr Separation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Cerebellar Ataxia and Chorea: Genetic Etiologies and Key Considerations for Diagnosis and Management.

Movement disorders clinical practice·2026
Same author

Managing acculturation threats with tailored self-affirmation interventions: A mixed-methods study with Syrian forced migrants.

The British journal of social psychology·2026

Related Experiment Video

Updated: Jan 9, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

14.7K

Evaluating Thalamic Biomarkers for Closed-Loop Deep Brain Stimulation in Essential Tremor.

Michael Bender, He Zheng, Adolfo Ramirez-Zamora

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |December 3, 2025
    PubMed
    Summary

    Local field potential (LFP) signals from thalamic nuclei show promise as biomarkers for detecting movement in Essential Tremor patients undergoing deep brain stimulation (DBS). Combining signals from dual leads significantly improves detection accuracy for adaptive DBS.

    More Related Videos

    Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
    14:14

    Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

    Published on: August 12, 2018

    9.3K
    A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
    07:14

    A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

    Published on: May 31, 2016

    15.3K

    Related Experiment Videos

    Last Updated: Jan 9, 2026

    MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
    05:54

    MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

    Published on: December 13, 2017

    14.7K
    Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
    14:14

    Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

    Published on: August 12, 2018

    9.3K
    A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
    07:14

    A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

    Published on: May 31, 2016

    15.3K

    Area of Science:

    • Neuroscience
    • Biomedical Engineering
    • Neurological Disorders

    Background:

    • Deep brain stimulation (DBS) and local field potential (LFP) recordings are key for closed-loop systems in Essential Tremor (ET).
    • Identifying reliable biomarkers for movement detection is crucial for adaptive DBS therapies.

    Purpose of the Study:

    • To evaluate LFP band power and inter-lead coherence as biomarkers for intended movement detection in an ET patient.
    • To assess the potential of dual-lead thalamic recordings for closed-loop DBS applications.

    Main Methods:

    • Recorded LFPs from ventral intermediate (VIM) and ventralis-oralis (VO) nuclei using Medtronic Percept™ RC neurostimulator and SenSight electrodes.
    • Patient performed Drink Cup and postural holding tasks, with simultaneous accelerometer data collection.
    • Generalized linear models (GLMs) and ROC curves analyzed LFP data for movement onset decoding.

    Main Results:

    • Individual leads showed task- and band-specific performance (e.g., VIM in Delta for Drink Cup, VO in Beta for Posture).
    • Integrating LFP data from both VO and VIM leads significantly enhanced movement detection performance (AUC > 0.71).
    • VO lead LFP signals demonstrated potential as biomarkers for closed-loop DBS in ET.

    Conclusions:

    • This study is the first to show LFP signals from the thalamus's ventralis-oralis nucleus as a potential biomarker for closed-loop DBS in Essential Tremor.
    • Integrating data from dual VO and VIM leads substantially improves movement detection.
    • These findings support the development of more effective, adaptive closed-loop DBS for ET and other movement disorders.