Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

806
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
806
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K
Fractures: Bone Repair01:27

Fractures: Bone Repair

4.9K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
4.9K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

5.3K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
5.3K
Burn Injuries01:22

Burn Injuries

4.0K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Fracture Healing Odyssey: Kinematic Comparison of Unions and Nonunions in Human Lower-Extremity Long Bones Treated with Intramedullary Nailing: A Retrospective Cohort Study.

The Journal of bone and joint surgery. American volume·2026
Same author

Intrawound Tobramycin Plus Vancomycin to Prevent Surgical Site Infection in Tibial Fractures: The TOBRA Randomized Clinical Trial.

JAMA·2026
Same author

Drug Reaction with Eosinophilia and Systemic Symptoms Following Antibiotic Cement Spacer Placement: A Case Report.

JBJS case connector·2026
Same author

Treatment and Outcomes for Gunshot Wound Humerus Fractures: A Multicenter Analysis.

Journal of orthopaedic trauma·2025
Same author

Polysomnographic insights into the attention-deficit/hyperactivity disorder and obstructive sleep apnea connection in children.

Frontiers in sleep·2025
Same author

Artificial intelligence in orthopaedic education: a narrative review.

Annals of joint·2025
Same journal

Preoperative Copper-to-Zinc Ratio and Postoperative Delirium After Hip Fracture Surgery: A Propensity Score-matched Cohort Study.

Orthopedics·2026
Same journal

Supracondylar Distal Femur Fracture Fixation: Early Experiences Comparing the Retrograde Nail With Locking Attachment Washer (LAW) Plate to Traditional Fixation Techniques.

Orthopedics·2026
Same journal

Intra-Articular Vancomycin Powder in Primary Total Knee Arthroplasty: A Retrospective Observational Study.

Orthopedics·2026
Same journal

Limb Salvage Versus Amputation for the Management of Primary Bone Tumors of the Upper Extremity: A Systematic Review.

Orthopedics·2026
Same journal

A Modified Keshishyan Index Demonstrates Three-dimensional Assessment of Asymmetry in Pediatric Pelvic Fractures.

Orthopedics·2026
Same journal

Planned Versus Intraoperative Vascular Surgery Consultations in Orthopedic Oncology.

Orthopedics·2026
See all related articles

Related Experiment Video

Updated: Jan 9, 2026

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
04:37

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

1.2K

Acute Alcohol Intoxication and Chronic Alcohol Use Increase Risk of Infection After Open Tibia Fractures.

Chirag Soni1, Elliott J Druten1, Michael Orcutt1

  • 1Department of Orthopaedic Surgery.

Orthopedics
|December 3, 2025
PubMed
Summary
This summary is machine-generated.

Acute and chronic alcohol use increase the risk of fracture-related infection (FRI) in open tibia fractures. Combined alcohol use presents a compounded risk, highlighting the need for interventions in this patient group.

More Related Videos

Pseudofracture: An Acute Peripheral Tissue Trauma Model
10:08

Pseudofracture: An Acute Peripheral Tissue Trauma Model

Published on: April 18, 2011

15.2K
A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection
06:56

A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection

Published on: February 20, 2020

9.0K

Related Experiment Videos

Last Updated: Jan 9, 2026

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
04:37

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

1.2K
Pseudofracture: An Acute Peripheral Tissue Trauma Model
10:08

Pseudofracture: An Acute Peripheral Tissue Trauma Model

Published on: April 18, 2011

15.2K
A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection
06:56

A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection

Published on: February 20, 2020

9.0K

Area of Science:

  • Orthopedic Surgery
  • Trauma Care
  • Infectious Disease

Background:

  • Alcohol consumption is a recognized risk factor impacting wound healing.
  • Open tibia fractures present a significant challenge in orthopedic trauma care.
  • Fracture-related infections (FRI) are a serious complication following orthopedic injuries.

Purpose of the Study:

  • To investigate the association between acute and chronic alcohol consumption and the incidence of fracture-related infections (FRI) in patients with open tibia fractures.
  • To determine if alcohol use modifies the risk of developing FRI in orthopedic trauma patients.
  • To identify specific risk factors contributing to FRI in the context of alcohol use.

Main Methods:

  • Retrospective review of skeletally mature patients with open tibia fractures treated at a level I trauma center (2017-2021).
  • Inclusion criteria required a six-month follow-up and available blood toxicology results.
  • Acute alcohol use defined by ethanol levels >10 mg/dL on admission; chronic alcohol use by daily consumption or documented history. FRI was the primary outcome, analyzed using bivariate and multivariate methods.

Main Results:

  • Of 190 fractures, 36.8% developed FRI (15 suggestive, 55 confirmatory).
  • Both acute and chronic alcohol use were independently linked to suggestive FRI (OR 2.96 and 4.70, respectively).
  • Concomitant acute and chronic alcohol use significantly elevated suggestive FRI risk (OR 11.05). Smoking, compartment syndrome, and fracture severity increased confirmatory FRI risk.

Conclusions:

  • Acute and chronic alcohol use are significant risk factors for suggestive fracture-related infections in open tibia fractures.
  • The combined presence of acute and chronic alcohol use exacerbates the risk of suggestive FRI.
  • Findings emphasize the need for targeted interventions for alcohol-using patients in orthopedic trauma to mitigate infection risk.