Three New Phenolic Compounds From the Twigs and Leaves of Casearia glomerata
Na Li1, Zi-Qi Jin1, Jing-Jing Zhang1,2
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Medicine, School of Pharmacy, and School of Chemical Science and Technology, Yunnan University, Kunming, China.
Abstract:
Phytochemical studies of the twigs and leaves of Casearia glomerata yielded three previously undescribed phenolic compounds, including two phenylpropanoid derivatives, Casearata A (1) and Casearata B (2), one butyrolactone, Casearata C (3), as well as eleven known compounds 4-14. Their structures were elucidated by nuclear magnetic resonance, infrared, mass spectrometry, and ultraviolet spectroscopy. The absolute configurations of the new compounds were determined by a combination of linear correlation coefficients (R2), DP4+ probability analysis, and electronic circular dichroism calculations. The cytotoxic activity of compounds 1-4 and 6-14 was evaluated. Among these, compound 7 exhibited weak inhibitory effects against MDA-MB-231, HCT-116, HepG2, and A549 tumor cell lines, with IC50 values of 21.70-39.08 µM.
