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Published on: November 30, 2022
Cobalt-Catalyzed Borylation of Arenes Enabled by in Situ π-Coordination
Akash G Tathe1, Yuichiro Mutoh1, Laurean Ilies1
1RIKEN, Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Abstract:
π-Coordination of an arene to chromium enables cobalt-catalyzed C-H borylation with a simple catalytic system consisting of commercially available compounds, [Co(acac)2] and a terpyridine derivative. Arenes can be directly borylated via in situ ligand exchange with a chromium η6-naphthalene precursor in a one-pot, two-step reaction. Electron-rich arenes, which have been a challenging substrate for cobalt-catalyzed C-H borylation, react well under these conditions, presumably because η6-coordination to chromium decreases the electron density on the arene to enhance the C-H activation step.
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