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DDX21 nuclear-cytoplasmic shuttling recruits RPS18 to viral dsRNA to promote CSFV replication

Bingke Li1, Bolun Zhou2, Chenchen Sun1

  • 1College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou 510642, China.

Veterinary Microbiology
|December 3, 2025
PubMed
Summary

Classic Swine Fever Virus (CSFV) hijacks DEAD-box helicase 21 (DDX21), moving it to the cytoplasm. This interaction enhances viral protein synthesis by recruiting ribosomal protein S18 (RPS18), aiding CSFV replication.

Keywords:
Classical swine fever virus (CSFV)Nuclear-cytoplasmic translocation，DEAD-box RNA helicase 21 (DDX21)Ribosomal protein S18 (RPS18)Ribosomal protein spatial controlViral translation hijacking

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