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Updated: Jan 9, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
One-hour post-load plasma glucose thresholds for intermediate hyperglycemia and type 2 diabetes mellitus diagnosis in
Yimeng Wang1, Qiuxia Wu2, Xiaolong Wang2
1National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China.
Aims:
To define the optimal 1-h PG cutoff values for intermediate hyperglycemia (IH) and type 2 diabetes mellitus (T2DM) in the Chinese population.
Methods:
A total of 927 study participants across the spectrum of glucose tolerance were enrolled to establish the optimal 1-h PG thresholds for IH and T2DM based on maximum Youden index. All individuals were subsequently reclassified according to the optimal 1-h PG thresholds. The consistency of the classification results between the 1-h PG thresholds and traditional OGTT criteria was further assessed by the weighted kappa coefficient.
Results:
The optimal 1-h PG cutoff values were 9.63 mmol/L for IH and 13.04 mmol/L for diabetes, exhibiting higher Youden index and specificity but lower sensitivity than the recommended cutoff values. Among individuals with normal glucose tolerance, those with elevated 1-h PG levels exhibited higher insulin levels under glucose stimulation. Strong agreement was observed between the two classification criteria (weighted Cohen's κ = 0.600, 95 % CI 0.553-0.646).
Conclusions:
In the Chinese population, the optimal 1-h PG thresholds for IH and T2DM were 9.63 mmol/L and 13.04 mmol/L, respectively, indicating the best balance between specificity and sensitivity.
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