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Maccosas G-L, six previously undescribed flavonoids isolated from Maclura fruticosa and their anti-inflammatory
Jing-Jing Zhang1, Yan-Ling Tang2, Xue-Mei Zhou2
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming 650500, China; Southwest United Graduate School, Kunming, 650092, China.
Abstract:
Phytochemical investigation of Maclura fruticosa (Moraceae) yielded twelve flavonoids from its twigs and leaves, including six undescribed compounds: five prenylated isoflavones (maccosas G-K, 1-5) and one benzylated dihydroflavonol (maccosa L, 6), alongside six known analogues (7-12). Structural elucidation was accomplished through NMR, HRESIMS, and ECD analyses. The anti-inflammatory activity of all the isolated compounds was screened and three benzylated dihydroflavonols (6, 11 and 12) exhibited potent anti-inflammatory activities. Compound 6 decreased LDH level in a dose-dependent manner, showing IC50 value of 8.53 μM.
