Related Experiment Video

Updated: Jan 9, 2026

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

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Differential therapeutic implications of the OSM-OSMR signaling pathway in cancer and inflammatory diseases

Chenyue Tang1, Jinna Li2, Yujin Chen1

  • 1Department of Neurosurgery, The First Hospital of China Medical University, Nanjing Street 155, Heping District, Shenyang, Liaoning, 110001, China.

International Journal of Biological Macromolecules
|December 3, 2025
PubMed

Insights

The Oncostatin M (OSM)-OSMR signaling pathway drives cancer and inflammation. Targeting this pathway with novel therapies shows promise for treating both refractory tumors and inflammatory conditions.

Area of Science:

  • Biochemistry
  • Immunology
  • Oncology

Background:

  • The OSM-OSMR signaling pathway is implicated in cancer and inflammatory diseases.
  • OSMR activation of the JAK/STAT axis promotes tumorigenesis and modulates the tumor microenvironment.
  • This pathway exacerbates inflammation in conditions like myocardial infarction and inflammatory bowel disease.

Purpose of the Study:

  • To review the clinical significance of the OSM-OSMR signaling pathway in cancer and inflammatory diseases.
  • To highlight OSMR as a potential biomarker and therapeutic target.

Main Methods:

  • Literature review of studies on the OSM-OSMR signaling pathway.
  • Analysis of the role of OSM-OSMR in tumorigenesis and inflammation.
  • Evaluation of emerging targeted therapies.

Main Results:

  • OSM-OSMR signaling drives tumor progression by activating the JAK/STAT axis and remodeling the tumor microenvironment.
  • OSM-OSMR contributes to persistent inflammation in various diseases.
  • OSMR is a key biomarker for tumor diagnosis and prognosis.

Conclusions:

  • The OSM-OSMR pathway is clinically significant in both cancer and inflammatory diseases.
  • Targeted therapies against OSM/OSMR show therapeutic potential for refractory tumors and inflammatory conditions.
  • OSMR is a promising therapeutic target for diverse diseases.
Keywords:
Inflammatory diseasesOSMOSMRTargeted therapyTumor microenvironment

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