Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teratogenicity01:07

Teratogenicity

3.9K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.9K
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

2.8K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.8K
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

176
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
176
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

2.1K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
2.1K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

718
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
718

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reducing Exposure Before Birth: An Interrupted Time Series Study of Prenatal Exposure to Fetotoxic Medications Under Risk Management Plans in Canada.

Clinical pharmacology and therapeutics·2026
Same author

Medication Exposure Definitions in Perinatal Pharmacoepidemiology: Implications for Pregnancy Studies.

Paediatric and perinatal epidemiology·2026
Same author

Mind the Litter: The Critical Role of Intralitter Variables in Reproductive and Developmental Toxicology Research.

Birth defects research·2026
Same author

First-trimester asthma controller medication use and major congenital malformation risk in offspring of women with asthma: A nationwide population-based cohort study.

The Journal of allergy and clinical immunology·2026
Same author

Diarrhoea events in offspring exposed to tumour necrosis factor inhibitors and rotavirus vaccine: a population-based cohort study.

Rheumatology (Oxford, England)·2026
Same author

Benzene-induced growth restriction and compensatory rebound in mouse fetuses and placentas.

Reproductive toxicology (Elmsford, N.Y.)·2026
Same journal

Excerpts from the World Medical Literature: Reproductive Endocrinology and Infertility.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same journal

Surgical site infections associated with crash cesarean sections.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same journal

Risk of Recurrent Preterm Prelabour Rupture of Membranes: Role of Mid-Trimester Cervical Length Assessment.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same journal

Family Balancing and Reproductive Autonomy: Re-Examining the Ethics of Non-Medical Sex Selection in Canada.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same journal

Iron Deficiency in Women: A Practical Illustrated Review.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same journal

The Impact of Pathogenic Variants of BRCA1, BRCA2 and Other DNA-Repair Genes on the Survival Benefits Conferred by PARP Inhibitors - Single Center Experience from Quebec.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
See all related articles

Related Experiment Video

Updated: Jan 9, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

87.5K

Acetaminophen Use During Pregnancy and Neurodevelopmental Risk: Biological Plausibility.

Delaine Pereira1, Anick Bérard2, Justine Pleau2

  • 1Department of Biomedical and Molecular Sciences, and School of Environmental Studies, Queen's University, Kingston, ON.

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|December 3, 2025
PubMed
Summary
This summary is machine-generated.

Acetaminophen use during pregnancy is not definitively linked to neurodevelopmental issues. Current evidence is limited, supporting its cautious use as recommended by the Society of Obstetricians and Gynaecologists of Canada.

Keywords:
acetaminophenmechanismsneurotoxicitypregnancy

More Related Videos

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
05:13

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

575
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.7K

Related Experiment Videos

Last Updated: Jan 9, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

87.5K
Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
05:13

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

575
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.7K

Area of Science:

  • Perinatal research
  • Neurodevelopmental toxicology
  • Pharmacology in pregnancy

Background:

  • Acetaminophen (paracetamol) is widely used for pain and fever during pregnancy.
  • Concerns exist regarding potential neurodevelopmental effects in offspring exposed in utero.
  • Mechanistic pathways have been proposed but require further investigation.

Purpose of the Study:

  • To review mechanistic evidence on acetaminophen's potential impact on fetal neurodevelopment.
  • To discuss the limitations of current animal and in vitro models.
  • To evaluate the consistency of evidence supporting or refuting a causal link.

Main Methods:

  • Review of mechanistic studies (animal, in vitro) on acetaminophen and neurodevelopment.
  • Consideration of limitations and human relevance of experimental models.
  • Synthesis of current human epidemiological data.

Main Results:

  • Proposed mechanistic pathways include oxidative stress, altered transporter expression, and epigenetic changes.
  • Animal and in vitro models have limitations in predicting human outcomes.
  • Existing human and mechanistic data are insufficient to establish causality at typical doses.

Conclusions:

  • Current evidence does not support a causal link between therapeutic acetaminophen use in pregnancy and adverse neurodevelopmental outcomes.
  • The Society of Obstetricians and Gynaecologists of Canada's recommendation for cautious use is supported.
  • Further high-quality research is needed to clarify potential risks.