Related Experiment Video
Updated: Jan 9, 2026
04:40
Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
Published on: January 5, 2024
3.1K
Real-World Safety and Effectiveness of Rivaroxaban in Cancer-Associated Venous Thromboembolism (PRIMECAST) - A
Yuichi Tamura1,2, Norihiro Kondo3, Fumie Tsukada3
1Department of Cardiology, International University of Health and Welfare School of Medicine, Mita Hospital.
Summary
Rivaroxaban effectively treated cancer patients with venous thromboembolism (VTE) in Japan, showing a 98.0% VTE recurrence-free survival rate. This real-world study confirms low rates of VTE recurrence and related deaths during treatment.
Area of Science:
- Oncology
- Hematology
- Pharmacology
Background:
- Real-world data on cancer patients with venous thromboembolism (VTE) receiving rivaroxaban in Japan is limited.
- Venous thromboembolism is a significant complication in cancer patients, impacting outcomes and treatment.
Purpose of the Study:
- To evaluate the clinical outcomes of Japanese cancer patients with VTE treated with rivaroxaban.
- To assess the efficacy and safety of rivaroxaban in this specific patient population.
Main Methods:
- Prospective, observational study conducted across 27 Japanese institutions.
- Enrolled cancer patients with VTE treated with rivaroxaban or warfarin from August 2018 to December 2021.
- Analyzed outcomes for 322 patients receiving rivaroxaban.
Main Results:
- Kaplan-Meier estimate showed a VTE recurrence/worsening-free survival rate of 98.0% over 24 weeks.
- No VTE-related deaths were observed during the treatment period.
- No cardiovascular deaths occurred in the rivaroxaban-treated group.
Conclusions:
- Rivaroxaban demonstrated high efficacy in preventing VTE recurrence and worsening in Japanese cancer patients.
- The treatment showed a favorable safety profile with no VTE-related or cardiovascular deaths.
- These findings support the use of rivaroxaban for managing VTE in cancer patients in a real-world Japanese setting.
Related Concept Videos
01:29Venous Thrombosis III: Interprofessional Care
265
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
265
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
275
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
275
01:30Venous Thrombosis I: Introduction
310
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
310
01:30Venous Thrombosis IV: Nursing Management
185
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
185
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
281
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
281
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
382
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
382