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Orchestrating tumor-immune epigenetics via SERT-H3Q5ser axis

Canhui Cao1

  • 1National Clinical Research Center for Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430199, China; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430199, China; Department of Obstetrics and Gynecology, Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Trends in Cancer
|December 3, 2025
PubMed
Summary

The serotonin transporter (SERT) and histone H3 serotonylation (H3Q5ser) link neurotransmitter signals to cancer epigenetics. Targeting this neuro-epigenetic axis may offer new cancer immunotherapies and treatments.

Keywords:
H3Q5serhistone H3 serotonylationserotoninserotonin transportertumor immunity

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