Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

6.1K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
6.1K
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

164
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
164
Drug Regulation01:25

Drug Regulation

2.7K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
2.7K
Pharmacovigilance01:19

Pharmacovigilance

1.6K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.6K
Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

275
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
275
Drug Discovery: Overview01:26

Drug Discovery: Overview

10.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Prediction of malnutrition in kids by integrating ResNet-50-based deep learning technique using facial images.

Scientific reports·2026
Same author

Simultaneous measurement of linear and angular displacement sensor using POF based on macro-bend loss.

Scientific reports·2026
Same author

A process-guided uncertainty-aware deep learning framework for reliable and interpretable industrial fault diagnosis.

PloS one·2026
Same author

Self-defending 6G networks through AI-driven adaptive decoy generation at the edge.

Scientific reports·2026
Same author

Multi-View Transformers for Structure-Aware HA-NA Drift Risk Scoring and Mutation Hotspot Mapping.

Viruses·2026
Same author

A multi-scale adaptive filtering and AtRes_SRU-transformer synergy for breast cancer histopathology classification.

Scientific reports·2026

Related Experiment Video

Updated: Jan 9, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.1K

A DAG-enabled cryptographic framework for secure drug traceability with identity-bound authentication and anomaly

Rajkumar S C1, Yuvasini D2, Musiri Kailasanathan Nallakaruppan3

  • 1Department of Computer Science and Engineering, Anna University Regional Campus Madurai, Keelakuilkudi, Madurai, 625019, Tamil Nadu, India.

Scientific Reports
|December 3, 2025
PubMed
Summary

This study introduces a secure drug traceability framework using Directed Acyclic Graph (DAG) ledgers and Near Field Communication (NFC) tags to combat counterfeit pharmaceuticals. The system offers real-time monitoring and anomaly detection for a safer drug supply chain.

Keywords:
Aadhaar-linked authenticationAnomaly detectionDAG ledgerDrug traceabilityEdge computingEncrypted NFC tags

More Related Videos

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
11:14

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

Published on: October 2, 2016

12.1K
HPLC Coupled with Chemical Fingerprinting for Multi-Pattern Recognition for Identifying the Authenticity of Clematidis Armandii Caulis
07:29

HPLC Coupled with Chemical Fingerprinting for Multi-Pattern Recognition for Identifying the Authenticity of Clematidis Armandii Caulis

Published on: November 11, 2022

2.4K

Related Experiment Videos

Last Updated: Jan 9, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.1K
Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
11:14

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

Published on: October 2, 2016

12.1K
HPLC Coupled with Chemical Fingerprinting for Multi-Pattern Recognition for Identifying the Authenticity of Clematidis Armandii Caulis
07:29

HPLC Coupled with Chemical Fingerprinting for Multi-Pattern Recognition for Identifying the Authenticity of Clematidis Armandii Caulis

Published on: November 11, 2022

2.4K

Area of Science:

  • Computer Science
  • Information Security
  • Supply Chain Management

Background:

  • Counterfeit pharmaceuticals pose a significant global public health risk.
  • Limited regulatory oversight and digital traceability exacerbate the problem, especially in resource-constrained regions.
  • Existing systems often lack the real-time monitoring and decentralized security needed for effective pharmaceutical supply chains.

Purpose of the Study:

  • To propose and evaluate a cryptographically anchored drug traceability framework using Directed Acyclic Graph (DAG) ledgers.
  • To enhance pharmaceutical supply chain security, decentralization, and verifiability.
  • To address the challenges of counterfeit drugs in regions with limited regulatory enforcement.

Main Methods:

  • Developed a decentralized traceability framework utilizing Directed Acyclic Graph (DAG) ledger technology.
  • Integrated encrypted Near Field Communication (NFC) tags (NTAG424 DNA) with Aadhaar-linked identities for secure, identity-bound authentication.
  • Employed a hybrid deep learning model (LSTM-CNN) for anomaly detection, trained on simulated datasets with environmental and behavioral covariates.
  • Utilized edge-ledger buffering for offline/rural deployments and Merkle-root anchoring for eventual DAG synchronization.

Main Results:

  • Achieved 94.5% anomaly detection precision and 0.92 traceability accuracy in a simulated environment.
  • Demonstrated a median latency of 85 ms, suitable for real-time monitoring.
  • The DAG structure facilitated parallel transaction validation, zero fees, and low-latency edge operations.
  • The system showed potential for scalability and privacy preservation under controlled conditions.

Conclusions:

  • The proposed DAG-NFC framework is simulation-based feasible for secure and interoperable pharmaceutical traceability.
  • The system effectively addresses key challenges in combating counterfeit drugs.
  • Further real-world validation and regulatory assessment are necessary for full operational deployment.