Association Between Sedentary Behavior Patterns and Glycemic Outcomes in Women with Overweight and Obesity Under...

This study investigates whether sedentary behavior patterns-such as inter-day variability and intraday accumulation patterns-are associated with dynamic glycemic outcomes, an association not previously examined in women with overweight and obesity.

Fifteen participants (age: 20.6 ± 1.0 years; BMI: 28.1 ± 2.2 kg/m²) underwent simultaneous accelerometer and continuous glucose monitoring. Associations between sedentary behavior patterns (including breaks in sitting, time spent in ≥ 30-min sedentary bouts, and median sedentary bout duration), and their inter-day variability computed as the coefficient of variation (CV), and overall glycemic outcomes were examined using linear regression. Intraday associations between daytime sedentary behavior patterns and time-matched daytime and subsequent nighttime glycemic outcomes were examined using linear mixed models.

Data from 144 person-days were analyzed. After adjustment for total sitting time and relevant covariates, a higher inter-day variability in time spent in ≥ 30-min sedentary bouts was associated with a higher percentage of time spent within the target glucose range (β = 1.281% 95% CI [0.107, 2.454], P = 0.037). A longer intraday median sedentary bout duration was associated with an increased nighttime CV of glucose (β = 0.13% 95% CI [0.012, 0.248], P = 0.031).

Women with overweight and obesity who alternated between days with more prolonged (≥ 30 min) sitting and days with less, and who had a shorter median sedentary bout duration, showed more favorable glycemic outcomes.