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A simple method that doubles learning speed for mice in touchscreen-based visual discrimination.

Yuji Kiyama1, Yusuke Suzuki2,3, Misako Haraguchi1

  • 1Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima-shi, Kagoshima, 890-8544, Japan.

Scientific Reports
|December 3, 2025
PubMed
Summary

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This summary is machine-generated.

New touchscreen training methods significantly speed up visual discrimination learning in mice. These enhanced protocols improve cognitive assessments and enable more complex behavioral experiments in preclinical research.

Area of Science:

  • Behavioral neuroscience
  • Animal cognition
  • Preclinical research

Background:

  • Touchscreen operant learning systems are crucial for assessing cognitive function in mice.
  • Traditional visual discrimination (VD) task training protocols are time-consuming.
  • There is a need for more efficient training methods in behavioral neuroscience.

Purpose of the Study:

  • To develop and validate modified touchscreen training protocols to enhance learning efficiency in VD tasks for mice.
  • To investigate the impact of consecutive screen touches and visual feedback on learning speed and accuracy.
  • To assess the utility of the enhanced protocol for initial learning, reversal learning, and serial reversal tasks.

Main Methods:

  • Mice were trained using modified touchscreen protocols requiring two or three consecutive touches for stimulus selection.
Keywords:
Cognitive flexibilityOperant learningVisual discrimination

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  • Trials were reset upon inconsistent responses.
  • Visual feedback was provided after incorrect choices.
  • The protocol was tested on initial VD learning, reversal learning, and serial reversal tasks.

    • Main Results:

    • The modified protocols significantly accelerated task acquisition speed in mice.
    • Incorporating visual feedback further enhanced learning speed and task accuracy.
    • Mice rapidly acquired both initial and reversal VD learning, even with multiple stimulus pairs.
    • Performance improved across sessions in serial reversal tasks, indicating enhanced rule acquisition and cognitive flexibility.

    Conclusions:

    • Simple adjustments to touchscreen training protocols can substantially improve learning efficiency in mice.
    • These enhanced protocols facilitate more complex cognitive assessments and behavioral experiments.
    • The findings have implications for advancing preclinical research in behavioral neuroscience.