Related Experiment Video
Updated: Jan 9, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
The Impact of Lasers and Energy-Based Devices on Cellular Senescence: A Systematic Review
Ryan C Kelm1,2, Morgan B Murphrey1,2
1Dermatology, Laser, & Cosmetic Center, Department of Dermatology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Objectives:
Cellular senescence contributes to skin aging. Lasers and energy-based devices (EBDs) are used to treat age-related skin changes. Given the clinical improvement seen with these devices, we sought to systematically review whether current evidence supports an impact on cellular senescence.
Methods:
A systematic literature review was conducted according to PRISMA guidelines. PubMed, EBSCO, and Web of Science databases were searched for relevant articles examining the effects of lasers and EBDs on cellular senescence. Devices included lasers, radiofrequency, ultrasound, photobiomodulation, photodynamic therapy, and intense pulsed light.
Results:
A total of 23 articles presented original work, relevant to dermatology, evaluating the impact of these treatments at a cellular level. These comprised laser (n = 6), light-based (n = 11), and other EBDs (n = 6). Overall, these technologies demonstrated a positive effect on cellular senescence and clinically minimized neocarcinogenesis and improved age-related skin changes.
Conclusions:
Literature evaluating the impact of lasers and EBDs on cellular senescence is scarce. This review suggests that these modalities may reduce cellular senescence, thereby restoring cellular signaling and rejuvenating the skin. We propose that these effects represent a converging fundamental mechanism of hormesis promoting skin anti-fragility and longevity.
Related Concept Videos
Replicative Cell Senescence
The Effect of Aging on Tissues
Mitochondria
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Telomeres and Telomerase
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...

