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Paediatric Virilizing Ovarian Tumors: A Systematic Review
Shruthi Ravindra1, Satish Kumar Samal1, Melkunte Shanthaiah Dhananjaya1
1Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India.
Virilizing ovarian tumors (VOT) are rare in children. This systematic review highlights their varied clinical presentation, hormonal profiles, and age-specific histology, emphasizing the need for further research.
Area of Science:
- Pediatric Endocrinology
- Gynecologic Oncology
- Oncology
Background:
- Virilizing ovarian tumors (VOT) are rare in the pediatric population.
- Limited literature exists on their clinical spectrum, hormonal profile, imaging, histology, and outcomes.
- This study systematically reviews the characteristics of pediatric VOT.
Conclusions:
- Hyperandrogenic manifestations are less frequent in children under 8 years with VOT.
- Elevated 17-hydroxyprogesterone (17-OHP) and/or dehydroepiandrosterone sulfate (DHEAS) do not exclude VOT.
- The etiological spectrum of pediatric VOT is age-specific, warranting further multicenter studies for prognosis and management.
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