[Research progress on the mechanism of reabsorption after massive migrated lumbar disc herniation]

Lumbar disc herniation refers to a syndrome mainly characterized by low back and leg pain caused by factors such as degeneration of the lumbar intervertebral disc, deterioration of the biomechanical environment, and formation of immune inflammatory reactions, which lead to the protrusion of intradiscal tissue and compression of nerves. In cases of massive migrated lumbar disc herniation, the nucleus pulposus is prolapsed and migrated, often accompanied by severe clinical symptoms and usually requiring surgical treatment. Since the phenomenon of resorption after lumbar disc herniation is discovered and proposed, relevant literature has continuously emerged. Some scholars have indicated that the resorption rate of massive migrated protrusions is higher, but its mechanism has not been fully clarified. This article reviews and summarizes the resorption mechanisms of massive migrated lumbar disc herniation in recent years. The current research contents mainly include immune inflammatory reactions, the formation of blood vessels and lymphatics, matrix metalloproteinases, dehydration, cell autophagy and apoptosis, and tension application. Based on the above mechanism theory of resorption, we believe that in the treatment of massive migrated LDH, inflammatory reactions should be maintained. At the same time, the patient's clinical symptoms should be used as the main surgical evaluation criterion to avoid unnecessary social, economic, and medical burdens caused by overtreatment.