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Cenobamate for Drug-Resistant Epilepsy: Initial Experience from a Single Tertiary Center
Tawfik Elsherbini1, Vanessa Léger2, Arline Aude Bérubé1,2
1Faculté de médecine, https://ror.org/0161xgx34Université de Montréal, Montreal, QC, Canada.
Summary
Cenobamate (CNB) effectively reduced seizure frequency in drug-resistant epilepsy (DRE) patients in a real-world setting. A significant portion achieved seizure freedom within 12 months, demonstrating CNB
Area of Science:
- Neurology
- Clinical Pharmacology
Background:
- Drug-resistant epilepsy (DRE) presents significant treatment challenges.
- Cenobamate (CNB) has demonstrated efficacy in clinical trials for DRE.
Purpose of the Study:
- To evaluate the real-world effectiveness and safety of Cenobamate (CNB) in a DRE population.
- To assess seizure frequency reduction and seizure freedom rates with CNB treatment.
Main Methods:
- Retrospective study conducted at a university epilepsy clinic.
- Involved 109 patients with DRE, with follow-up data at 3, 6, and 12 months.
- Median seizure frequency reduction and seizure freedom rates were analyzed.
Main Results:
- Median seizure frequency reduction was 50.0% at 3 months, 57.3% at 6 months, and 73.3% at 12 months.
- 25.9% of patients achieved seizure freedom at 12 months.
- CNB was discontinued in 8.3% due to adverse events or inefficacy.
Conclusions:
- Cenobamate (CNB) demonstrates significant real-world effectiveness in reducing seizures in DRE patients.
- CNB is generally well-tolerated, with a low discontinuation rate.
- Findings support the use of CNB as a valuable treatment option for DRE.
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