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Updated: Jan 9, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
Breast Cancer Susceptibility: Meta-Analysis of Cytochrome P450 2C19 (CYP2C19) and Estrogen Receptor-1 (ESR1) Genetic
Anu Shibi Anilkumar1, Sheena Mariam Thomas1, Ramakrishnan Veerabathiran1
1Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.
Introduction:
Breast Cancer (BC) is a leading cancer among women, influenced by genetic polymorphisms. This meta-analysis examines CYP2C19 (rs4244285) and ESR1 (rs2234693) polymorphisms and BC susceptibility.
Methodology:
A PRISMA-guided search analyzed genotypic and allelic frequencies across six CYP2C19 and nine ESR1 studies, with quality assessed by the Newcastle-Ottawa Scale and Hardy-Weinberg Equilibrium, spanning diverse ethnic groups.
Results:
Most models found no significant associations for CYP2C19 or ESR1. The GG genotype of CYP2C19 (rs4244285) showed a potential protective effect against BC.
Conclusion:
Genetic variability impacts BC risk. CYP2C19 (rs4244285) may offer protective effects. Further research is needed for personalized treatments.
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