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Postoperative Vaginoplasty Outcomes for Transgender and Nonbinary Patients in a U.S. County Safety-Net Health System
Elizabeth Kvach1,2, Ryan O'Connell3, Corey Walsh2
1Department of Family Medicine, Denver Health, Denver, Colorado, USA.
Transgender Health
|December 4, 2025
Summary
Postoperative outcomes for transgender and nonbinary (TNB) patients undergoing vaginoplasty at a safety-net hospital showed complication rates within published ranges. This supports the feasibility of offering these procedures in similar healthcare settings.
Area of Science:
- Medical research
- Surgical outcomes
- Gender-affirming care
Background:
- Transgender and nonbinary (TNB) individuals often face barriers to gender-affirming care.
- Vaginoplasty is a key component of gender affirmation surgery.
- Establishing surgical programs in safety-net hospitals can improve access to care.
Purpose of the Study:
- To characterize postoperative outcomes for transgender and nonbinary (TNB) patients undergoing vaginoplasty.
- To identify demographic and medical factors associated with surgical outcomes.
- To evaluate the safety and feasibility of a newly established vaginoplasty program in a safety-net hospital.
Main Methods:
- Retrospective chart review of electronic medical records for patients who underwent vaginoplasty (May 2018-April 2021).
- Data collected included demographics, surgical complications (major/minor), postoperative visits, physical therapy outcomes, and narcotic usage.
- Descriptive and bivariate statistical analyses were performed.
Main Results:
- 153 patients underwent vaginoplasty; 150 were included in the analysis with a median follow-up of 3.6 months.
- Major and minor complication rates were 28% and 66.7%, respectively. Common major complications included hemorrhage and infection.
- No demographic or medical characteristics were significantly associated with surgical complications.
Conclusions:
- Vaginoplasty complication rates in this safety-net hospital program were comparable to published ranges.
- The findings support the safety and feasibility of providing vaginoplasty in safety-net settings.
- This study highlights the potential for expanded access to gender-affirming surgeries.

