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Related Experiment Video

Updated: Jan 9, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
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Ryanodex Reduces Persistent Hippocampal Effects of Single Mild Traumatic Brain Injury in Rats.

Reed Berlet1, Isabel Bear1, Cassidy Kessinger1

  • 1Department of Neurosurgery, Endeavor Health, Evanston, Illinois, USA.

Neurotrauma Reports
|December 4, 2025
PubMed
Summary
This summary is machine-generated.

Mild traumatic brain injury (mTBI) causes lasting brain changes, but Ryanodex, a dantrolene formulation, may reduce this hippocampal dysfunction. This offers potential for acute TBI treatment.

Keywords:
calcium dysregulationneurodegenerationryanodine receptorstraumatic brain injury

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Area of Science:

  • Neuroscience
  • Cellular Biology
  • Pharmacology

Background:

  • Traumatic brain injury (TBI) is a global health issue with increasing emergency visits.
  • No FDA-approved treatments currently exist for mitigating TBI-induced brain damage or promoting recovery.
  • Even a single TBI can lead to persistent neurological deficits, potentially involving calcium (Ca 2+ ) dysregulation and ryanodine receptors.

Purpose of the Study:

  • To investigate the persistent neurological effects of a single mild TBI (mTBI) in a rat model.
  • To evaluate the therapeutic potential of Ryanodex, a dantrolene formulation, in attenuating mTBI-induced hippocampal dysfunction.

Main Methods:

  • A rat model of mild TBI was induced using controlled cortical impact.
  • Hippocampal synaptic transmission and neuronal excitability were assessed.
  • The effects of acute and subacute Ryanodex injections on mTBI-induced changes were examined.

Main Results:

  • Mild TBI did not alter glial fibrillary acidic protein or phosphorylated tau levels.
  • mTBI significantly enhanced hippocampal CA3-CA1 synaptic transmission and CA1 pyramidal cell excitability for at least 30 days.
  • Ryanodex administration significantly attenuated these persistent mTBI-induced hippocampal dysfunctions.

Conclusions:

  • Single mild TBI can cause persistent synaptic and neuronal hyperexcitability in the hippocampus.
  • Ryanodex demonstrates potential as an intervention to mitigate persistent hippocampal dysfunction following mTBI.
  • These findings suggest a potential clinical application for Ryanodex in acute TBI treatment.