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Coalition of explainable artificial intelligence and quantum computing in precision medicine.

Soumyadeep Ray1, Pronaya Bhattacharya2, Ebrahim A Mattar3

  • 1Department of Biotechnology, Amity University, Newtown, Kolkata, 700135, West Bengal, India.

Computational and Structural Biotechnology Journal
|December 4, 2025
PubMed
Summary

This survey explores how Explainable Artificial Intelligence (XAI) and Quantum Computing (QC) are converging to advance precision medicine. It highlights hybrid quantum-explainable AI frameworks for drug discovery and diagnostics, aiming for trustworthy healthcare.

Keywords:
Explainable artificial intelligencePrecision medicineQuantum computingQuantum machine learning

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Area of Science:

  • Quantum Computing
  • Explainable Artificial Intelligence
  • Precision Medicine

Background:

  • The integration of advanced AI and quantum computing presents new opportunities for personalized healthcare.
  • Explainable Artificial Intelligence (XAI) is crucial for understanding complex models in medicine.

Purpose of the Study:

  • To survey the convergence of XAI and QC in precision medicine from 2018-2025.
  • To introduce a taxonomy of hybrid and quantum-explainable approaches.
  • To identify barriers and future research directions.

Main Methods:

  • Review of quantum algorithms, quantum-machine-learning models, and XAI techniques.
  • Evaluation of NISQ hardware and encoding constraints.
  • Comparison of interpretability methods (SHAP, LIME, QSHAP, QLRP, TSBA).
  • Demonstration via case studies in drug toxicity prediction and disease flare forecasting.

Main Results:

  • Development of hybrid variational-quantum pipelines with XAI explanations.
  • Identification of practical barriers including noise, data encoding, regulation, and privacy.
  • Benchmarking of clinical quantum advantage and scalable QXAI frameworks.

Conclusions:

  • The convergence of XAI and QC offers a path toward trustworthy, scalable quantum-enabled precision healthcare.
  • Interdisciplinary efforts are needed to overcome current limitations and realize clinical quantum advantage.