Related Experiment Video
Updated: Jan 9, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
[Autoimmune Hepatitis: Up-to-Date Concepts]
1Sección Hepatología. Hospital C. Bonorino Udaondo. Ciudad Autónoma de Buenos Aires, Argentina. Sección Hepatología Hospital C. Bonorino Udaondo Ciudad Autónoma de Buenos Aires Argentina.
Abstract:
Autoimmune hepatitis is a rare pathology characterized by biochemical and histological alterations. Two subtypes are known: type I affects children and adults, and type II affects almost exclusively children. So far there are no specific diagnostic criteria and it is considered a pathology of exclusion, although there are certain laboratory and histological alterations related to this entity. It can be asymptomatic or symptomatic, and the treatment of choice is immunosuppression. The use of non-invasive methods such as elastography can be useful in follow-up surveillance, both to evaluate treatment and to prevent complications. In its evolution it can present advanced hepatic fibrosis, cirrhosis, requirement of liver transplantation and death due to hepatic insuffieciency. The aim of this review is to present the latest evidence related to autoimmune hepatitis.
Related Concept Videos
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastritis-I: Introduction and Types
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
What is the Immune System?
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and...

