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Updated: Jan 9, 2026

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults
Published on: February 28, 2025
[Intracholecystic Papillary Neoplasm: Rare Pathology of the Gallbladder. A Diagnostic Challenge]
Patricia López Penza1, Mauro Mallarino1, Alejandro Etcheverry1
1Cirujano General. Sanatorio Cantegril. Punta del Este. Maldonado, Uruguay. Sanatorio Cantegril Punta del EsteMaldonado Uruguay.
Introduction:
. Intracholecystic papillary neoplasia is characterized by exophytic growth of the gallbladder epithelium into its interior.
Clinical Cases:
We present two clinical cases with a gallbladder mass that underwent cholecystectomy given the risk of being malignant gallbladder polyps. The pathological anatomy certifies that they correspond to an intracholecystic papillary neoplasia.
Discussion:
. Intracholecystic papillary neoplasia is a rare pathology, whose incidence varies from 0.5 to 0.8%, predominates in females and affects patients with a mean age of 60 years. Macroscopically it appears as a gallbladder polyp. It is a lesion with potential risk of malignancy which is why it is considered a precursor lesion for the development of invasive gallbladder carcinoma. It is important to note that intracholecystic papillary neoplasia that progresses to invasive carcinoma has a better prognosis than gallbladder carcinoma that originates from another type of lesion.
Conclusion:
. The presence of an exophytic growth lesion at the gallbladder level should make us suspect intracholecystic papillary neoplasia, being recommended to perform cholecystectomy.
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