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Updated: Jan 9, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
[Therapeutic Approach to Gastroesophageal Reflux Disease]
Mariela Dulbecco1, Mauricio Guzmán1
1Unidad de Neurogastroenterología, Servicio de Gastroenterología, Hospital Interzonal General de Agudos General José de San Martín, Universidad Nacional de La Plata, Buenos Aires, Argentina. Unidad de Neurogastroenterología Servicio de Gastroenterología Hospital Interzonal General de Agudos General José de San Martín Buenos Aires Argentina.
Abstract:
Gastroesophageal reflux disease is one of the most frequent reasons for consultation in gastroenterological practice. Its diagnosis is a challenge since typical symptoms usually have a low sensitivity and specificity. No less challenging is its therapeutic approach, since it requires a comprehensive approach that must take into account the symptomatic presentation (typical esophageal symptoms or extra esophageal symptoms), endoscopic structural findings, and motor and functional characteristics. The correct identification of the phenotypes of gastroesophageal reflux disease is crucial to guide the best treatment in each case. In this review, it is proposed to provide the reader with the best therapeutic options according to each phenotype and in accordance with the best evidence currently available.
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