Breast Primary Follicular Lymphoma: Two Cases of a Rare Entity Treated With Radical Radiotherapy and Rituximab

Primary breast lymphoma (PBL) is a rare form of non-Hodgkin's lymphoma (NHL), characterized by lymphoma primarily affecting the breast tissue and not seen anywhere else in the body. Follicular breast lymphoma, a distinct histological variant of NHL, manifests with an even greater rarity within the context of breast tissue. The optimal therapeutic approach for these tumors remains controversial. Two cases of follicular lymphoma of the breast are hereby reported. The patients, aged 58 and 56 years, presented at the institution with a breast lump. A biopsy was subsequently performed, yielding a diagnosis of follicular lymphoma. The subjects underwent a positron emission tomography (PET)-computed tomography (CT) scan, which revealed hypermetabolic uptake in the respective breast nodules, with no further alterations. Consequently, they were staged as stage IE. Patients were offered a course of radical radiotherapy with concomitant rituximab. PET-CT scans five months after treatment from both patients revealed a complete metabolic response. In conclusion, we emphasize the role of radiotherapy and rituximab in the management of follicular breast lymphoma.