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Case Report: Rare meets rare-miliary prostate cancer brain metastasis
Jaspreet K Gill1, Jay Detsky2, Eyal Golan3
1Division of Medical Oncology, Odette Cancer Center, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Frontiers in Oncology
|December 4, 2025
Summary
Miliary brain metastasis (MM) is rare, especially from prostate cancer (PC). This report details two new cases of PC-related MM, highlighting its poor prognosis and association with neuroendocrine differentiation.
Area of Science:
- Neurology
- Oncology
- Radiology
Background:
- Miliary brain metastasis (MM) is a rare condition characterized by numerous small lesions in the brain, typically perivascular.
- Prostate cancer (PC) rarely metastasizes to the brain, and MM secondary to PC is exceptionally infrequent, with only one prior reported case.
- Neuroendocrine differentiation in prostate cancer is associated with a higher incidence of brain metastasis.
