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Updated: Jan 9, 2026
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
[Hepatocellular Carcinoma: Epidemiological Reality in Tucumán, Argentine Northwest]
Fernando Buabse1, Felipe Palazzo1, Ana Palazzo1
1Hospital Ángel Cruz Padilla. Hospital Ángel Cruz Padilla.
Introduction:
Hepatocellular carcinoma is the most common primary liver tumor (80 to 90%). It is the sixth most frequent tumor and the third that causes the most cancer-related deaths. 85% occurs in Asia and Africa. In Latin America and Argentina, it is not fully represented in the literature due to the socio-economic reality. Most hepatocellular carcinomas present on the basis of cirrhosis.
Objective:
To characterize the pidemiology of hepatocellular carcinoma in Tucumán, Argentina.
Material And Method:
A descriptive, multicentric, study of both public and private activity in the province was carried out. Based on international guidelines, diagnosis and treatment of patients with hepatocellular carcinoma were carried out.
Results:
There were 328 patients, with 109 (33.23%) women and 219 (66.76%) men. Of these patients, 294 (89.6%) had cirrhotic liver. The 5-year survival was 6.09% (n:20/328) in stage A and 0.914% (n:3/328) in stage B.
Conclusion:
The epidemiology of hepatocellular carcinoma in Tucumán, Argentina was updated; coinciding with the literature. From the epidemiological point of view it showed; a higher prevalence of the disease in males than in females; that stage D at the time of diagnosis was the most prevalent; and that the majority of patients suffered from previous liver diseases.
